Mycophenolic acid

Description: 
Therapeutic drug monitoring for patients on immunosuppressant drugs. Analysis by tandem mass spectrometry.

Please send a request form with adequate patient information and clear contact details to enable efficient communication of results.
Clinical details: 
Mycophenolic acid (MPA) is an immunosuppressive agent which exerts it's effect by inhibiting the growth of B and T cells of the immune system. It is important to monitor the blood concentration of MPA as at toxic concentrations patients are susceptible to a number of side effects including leukopenia and anaemia. At sub-therapeutic dosage patients may experience transplant rejection. MPA is increasingly used as a steroid-sparing treatment in other autoimmune mediated disorders, for example psoriasis.
Related condition or disease: 
Organ transplantation, immunosuppressive therapy, autoimmune disease, psoriasis
Reference range: 

Suggested therapeutic range: 1 – 3.5mg/L

Synonyms or keywords: 
Immunosuppressant, MPA, Mycophenolate, Mycophenolic acid
Units: 
mg/L
Department: 
Liver Pathology
Location: 
King's College Hospital
Sample type and Volume required: 
EDTA Plasma – 100ul minimum
Turnaround time: 
24 hours of sample receipt.
Criteria for acceptance / rejections of sample
Storage and transport: 
Same day: send ambient by courier Within 2 days: store refrigerated and then send ambient by courier More than 2 days: send frozen (dry ice not required)
Contacts:
Immunosuppressive Drug Monitoring (IDM) Service
020 3299 3147
kch-tr.KCHIDMService@nhs.net
Institute of Liver Studies
3rd Floor Cheyne Wing
King's College Hospital
Denmark Hill
London
SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Immunosuppressive Drug Monitoring (IDM) Service

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Last updated: 10/12/2021