Immunosuppressive Drug Monitoring (IDM) Service
Normal hours of operation are 9am to 5.30pm, Monday to Friday.
The IDM service provides timely measurement of immunosuppressive drug concentrations using liquid chromatography–mass spectrometry, with clinical interpretation, in order to optimise patient dosage and treatment.
The IDM service is accredited by UKAS (ref 8805 https://www.ukas.com/wp-content/uploads/schedule_uploads/00007/8805-Medi...) to ISO15189:2012.
The consultant-led service provides specialist support and results interpretation to the liver transplant programme at King’s College Hospital, and also to the wider transplant and autoimmune disease treatment programmes both nationally and internationally.
Drugs measured by IDM include tacrolimus, ciclosporin, sirolimus, mycophenolic acid (MPA), and everolimus. In addition, the anti-viral drug ribavirin can be measured on request.
The 5 main immunosuppressive drugs are measured daily, Monday to Friday. There is currently no weekend service, however a service is provided on Bank Holidays.
Results are usually available within 24 hours of sample receipt, and often on the same day if samples are received before 2pm. Urgent results can be available within as little as 2 hours or so if pre-arranged.
Results are notified to EPR, by secure email, and by hard copy.
Current research interests include the use of dried blood samples to measure tacrolimus; simultaneous measurement of whole blood immunosuppressive drugs; measurement of various lipids and metabolites to characterise immune dysfunction in acute-on-chronic liver failure; development of a method to measure phosphatidylethanol (PEth).
The IDM service is staffed by experienced clinical and biomedical scientists which not only ensures the integrity of results, but provides assistance and support to medical colleagues with clinical interpretation of results. Clinical leadership and oversight is provided by a consultant in liver transplant and HPB surgery.
The IDM request form is below. Please complete the request form as fully as possible, including dosage and sample times to aid result interpretation.
A copy of the departments User Handbook is available below