Everolimus

Description: 
Therapeutic drug monitoring for patients on immunosuppressant drugs. Analysis by tandem mass spectrometry. Assay run every day including weekends and bank holidays.

For same-day analysis, samples must be received by the laboratory by 14:00 on weekdays and 10:30 at weekends/bank holidays. Please give the laboratory prior notice if you are sending samples at the weekend/bank holiday (Mon-Fri 9:00-5:00 – 07738 897225 / 020 7188 9652). On weekends/bank holidays, the Scientist running the assay can be contacted on 07718 195096 (core hours 11:00 – 14:00).

Please send a request form with adequate patient information and clear contact details to enable efficient communication of results out of hours.
Clinical details: 
Everolimus is an immunosuppressant, used in the treatment of patients who have undergone solid organ transplants, including kidney and heart transplants. It is taken as tablet form usually once a day and it may be given alongside other immunosuppressants such as tacrolimus or cyclosporin or other anti-neoplastic drugs such as Exemestane in breast cancer.

Due to the narrow therapeutic index and potential adverse side effects, blood concentrations of Everolimus must be routinely monitored, usually on a pre-dose (trough) sample. This is especially important in the first few months after transplant, as the dose needs to be high enough to prevent rejection of the transplanted organ, but not so high that it causes serious adverse effects such as kidney failure and severe infection.




Reference range: 

No established therapeutic range. Please contact the laboratory to discuss.

Synonyms or keywords: 
Immunosuppressant
Units: 
Ug/L
Sample type and Volume required: 
EDTA whole blood, 4ml.
Call in advance: 
No.
Turnaround time: 
1 day.
Special sample instructions: 

Trough sample, or pre-dose sample is recommended. Factors affecting results or interpretation: Time taken since last dose.

Storage and transport: 
Samples should be received in the laboratory by 14:00 on weekdays and 10:30 on weekends and bank holidays for same-day results.
Contacts:
Immunosuppressant Service Laboratory at St Thomas'
020 7188 9652
St Thomas’ Hospital
North Wing - 4th Floor
Westminster Bridge Road
London SE1 7EH
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/11/2017