Warfarin Sensitivity/Resistance SNPs
Description:
Analysis of SNPs in the VKORC1, CYP2C9 & CYP4F2 genes associated with Warfarin resistance or sensitivity.
Clinical details:
Some patients show an apparent resistance or sensitivity to Warfarin when started on standard dosing regimes.
Individuals with the CYP2C9*2 and CYP2C9*3 genotype show impaired metabolism of warfarin and, therefore, require a lower dose compared to CYP2C9*1 individuals.
The T allele for the VKCORC1 1173C>T polymorphism is associated with a lower dose requirement.
Individuals homozygous (T/T) for the CYP4F2 450C>T polymorphism show a mild resistance, requiring approximately 1mg/day extra warfarin compared to C/C individuals.
Individuals with the CYP2C9*2 and CYP2C9*3 genotype show impaired metabolism of warfarin and, therefore, require a lower dose compared to CYP2C9*1 individuals.
The T allele for the VKCORC1 1173C>T polymorphism is associated with a lower dose requirement.
Individuals homozygous (T/T) for the CYP4F2 450C>T polymorphism show a mild resistance, requiring approximately 1mg/day extra warfarin compared to C/C individuals.
Reference range:
n/a
Synonyms or keywords:
VKORC1
CYP2C9
CYP4F2
Warfarin resistance
Warfarin sensitivity
Units:
n/a
Department:
Location:
Sample type and Volume required:
1 x Edta
Call in advance:
no
Turnaround time:
14 days
Storage and transport:
transport at ambient temperature
Contacts:
Molecular Haemostasis Laboratory at St Thomas'
020 7188 2798
Haemostasis and Thrombosis
North Wing - 4th floor
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday - Friday 09.00 - 17.00
North Wing - 4th floor
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday - Friday 09.00 - 17.00
Laboratory:
Last updated: 14/03/2017
