Analysis of the VKORC1 gene by PCR amplification and sequencing of the coding region and splice junctions.
Warfarin Resistance can be a significant clinical problem and may be due to drug, diet or compliance issues or may be genetic. The major cause of true hereditary warfarin resistance are mutations in the VKORC1 gene - polymorphisms in VKORC1 and cytochrome genes e.g. CYP2C9 may cause mild resistance. Analysis of VKORC1 is appropriate in patients showing significant resistance to warfarin dosing.
Mutations in VKORC1 have also been associated with warfarin sensitivity.
Synonyms or keywords:
Vitamin K epoxide reductase complex subunit 1.