Serum tryptase
Description:
Elevated concentrations of serum tryptase are found in patients with mastocytosis, in anaphylaxis and other direct mast cell degranulation events. The assay measures both alpha and beta subunits of tryptase. The investigation of suspected anaphylaxis requires that 3 blood samples are taken;
1) As soon as possible after onset of anaphylaxis, within one hour
2) Between 3 and 6 hours post-anaphylaxis
3) At least 24 hours after onset
This timescale allows the differentiation of true anaphylaxis and mastocytosis. In anaphylaxis the tryptase concentration will return to baseline post 24 hours whereas in mastocytosis the concentration remains high.
1) As soon as possible after onset of anaphylaxis, within one hour
2) Between 3 and 6 hours post-anaphylaxis
3) At least 24 hours after onset
This timescale allows the differentiation of true anaphylaxis and mastocytosis. In anaphylaxis the tryptase concentration will return to baseline post 24 hours whereas in mastocytosis the concentration remains high.
Reference range:
2 - 14
Units:
ug/L
Department:
Location:
Sample type and Volume required:
Clotted (Gold top vacutainer)
Turnaround time:
6 working days
Special sample instructions:
All tests are compromised by long transit times. For this reason the date of bleed and of postage must be provided with each request. This is an absolute requirement in the case of suspected anaphylaxis.
Storage and transport:
Serum stored at 4°C should be sent by first class post as soon as possible.
Time limit for extra tests:
6 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Laboratory:
Last updated: 07/08/2015
