Serum Free Kappa and Lambda Light Chains (SFLC)
Description:
Serum free light chain analysis by enzyme immunoassay
Clinical details:
Serum capillary electrophoresis may not detect all paraproteins due to factors like low concentration, inadequate electrophoretic separation or being present only in urine. In such instances quantifying serum free kappa and lambda light chains, calculating the κ:λ ratio and urine protein electrophoresis may help identify monoclonal proteins. The κ:λ ratio may be abnormal in amyloidosis, light chain disease and in impaired renal function.
Reference range:
Free kappa light chains 3.30 - 19.40 Free lambda light chains 5.71 - 26.30 Kappa/Lambda ratio 0.26 - 1.65
Units:
mg/L
Department:
Location:
Sample type and Volume required:
Clotted (Gold top vacutainer)
Turnaround time:
3 working days
Special sample instructions:
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Storage and transport:
Please contact laboratory if urgent analysis is required. Serum stored at 4°C should be sent by first class post
Time limit for extra tests:
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Laboratory:
Last updated: 23/05/2023
