PT20210G>A polymorphism

Description: 
Direct detection of F2 c.*97G>A (PT20210G>A) polymorphism.
Clinical details: 
The PT20210G>A polymorphism in the 3'UTR of the F2 gene is associated with raised plasma prothrombin levels and is a risk factor for venous thrombosis. It is found in ~1-2% of caucasians (more common in those of southern european descent) but is uncommon in other populations. Heterozygosity is associated with an approximately 3-fold increased risk of thrombosis and it is identified in ~6-8% of thrombophilia patients. Homozygosity is rare, ~1 in 10,000, so the relative risk of thrombosis is difficult to calculate.
Related condition or disease: 
Increased thrombophilia risk.
Increased plasma Prothrombin levels.
Reference range: 

n/a

Synonyms or keywords: 
PT20210 F2 Leiden (FII Leiden) Thrombophilia risk factor
Units: 
n/a
Department: 
Haemostasis and Thrombosis Department
Location: 
St Thomas' Hospital
Sample type and Volume required: 
1 x Edta
Call in advance: 
no
Turnaround time: 
7 days
Criteria for acceptance / rejections of sample
Storage and transport: 
transport at ambient temperature
Contacts:
Molecular Haemostasis Laboratory at St Thomas'
020 7188 2798
Haemostasis and Thrombosis
North Wing - 4th floor
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH

Laboratory opening times
Monday - Friday 09.00 - 17.00
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Molecular Haemostasis Laboratory at St Thomas'

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Last updated: 14/03/2017