PD-L1 Testing

Description: 
PD-L1 is an immune-related biomarker that is expressed on tumour cells in various tumour types, including Non Small Cell Lung Cancer (NSCLC). Assessing PD-L1 expression in squamous and non-squamous NSCLC may contribute to a better understanding of a patient's tumour and KEYTRUDA is indicated for the treatment of patients with metastatic NSCLC whose tumours express PD-L1. PD-L1 expression helps identify patients that are most likely to benefit from KEYTRUDA
Clinical details: 
The Dako PD-L1 22C3 pharmDx™ kit is a qualitative assay intended for use in the detection of PD-L1 in formalin-fixed, paraffin-embedded (FFPE) in non−small-cell lung carcinoma (NSCLC) using the Dako Autostainer Link 48 platform
Synonyms or keywords: 
Programmed Death Ligand 1
Sample type and Volume required: 
Sample Type: Formalin-fixed, paraffin-embedded (FFPE) slides
Volume: Fresh H&E slide and 3 unstained slides
Turnaround time: 
5 working days
Special sample instructions: 

Collection: unstained slides on positive-charged slides sectioned at 3 microns, sectioned of no more than one month age

Storage and transport: 
Refrigerate and protect from light and submit within 4 weeks of sectioning
Contacts:
Cellular Pathology at Guy's And St Thomas' Hospital
Histology: 0207 188 8468, Cytology: 0207 188 2915, Oral Pathology: 0207 188 4367
Histopathology & Cytopathology Laboratories
Cellular Pathology
St Thomas' Hospital
North Wing - 2nd Floor
Westminster Bridge Road
London SE1 7EH

Head and Neck/Oral Pathology Laboratory
4th Floor, Tower Wing
Guy's Hospital
Great Maze Pond
London SE1 9RT



For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 30/06/2016