Manganese

Description: 
Manganese by ICP-MS
Clinical details: 
Manganese is an essential trace element that acts as a catalyst for several enzymes involved in carbohydrate, glycosaminoglycan, and cholesterol metabolism. Manganese superoxide dismutase is found in mitochondria and is responsible for the inactivation of superoxide radicals. Deficiency of manganese may manifest as dermatitis with reduced cholesterol levels in males, although manganese deficiency in clinical practice is rare. Manganese intoxication results in a neurotoxic syndrome known as manganism and is a complication of total parenteral nutrition in those patients with hepatobillary disease.

Whole blood is the sample of choice for the measurement of manganese although plasma manganese can also be measured. As manganese is present in the steel used to make cannulas, it is advisable to collect a blood sample for manganese after another sample has been taken, or to discard the first 5 millilitres of blood before collection for manganese measurement. Alternatively a plastic cannula can be used.
Reference range: 

Blood: 120–325 nmol/L (children up to 1 yr) 73–210 nmol/L (children/adults greater than 1 yr) > 360 nmol/L Risk of toxicity Plasma: 9–24 nmol/L

Sample type and Volume required: 
4 mL EDTA whole blood
1 mL plasma/serum

Blood manganese samples may be prone to contamination from use of stainless steel needles or from vacutainer, during blood collection. Ideally a plastic cannula should be used or the first few mls of blood discarded or used for tests other than Mn (or other trace elements). Where contamination is suspected to be due to the vacutainer- a blank tube (clearly marked and from same lot number) should be included with the actual patient blood sample - for testing by the lab
Turnaround time: 
5–7 working days, 7-10 working days for whole blood samples
Special sample instructions: 

Use plastic cannula or second draw if metal needle essential

Contacts:
Toxicology Department at King's Hospital
020 3299 5881
kch-tr.toxicology@nhs.net
King's College Hospital
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
Trace Elements Laboratory at King's College Hospital
020 3299 3008
kishor.raja@nhs.net
King's College Hospital
Bessemer Wing - Top Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 16/02/2016