Fractionated faecal porphyrins

Description: 
Fractionated faecal porphyrins is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King’s College Hospital. Quantitative measurement of porphyrins and isomers is carried out using HPLC analysis.
Clinical details: 
Fractionation by HPLC is carried out when the total faecal porphyrins (TFP) is above the normal reference range to aid in the differentiation between the different types of porphyrias and secondary causes due to dietary causes or increased bacterial degradation of haem in the gut to protoporphyrin and dicarboxylate porphyrins.
Reference range: 

Total coproporphyrin (I + III) = <46 nmol/g dry wt, Dicarboxylate porphyrin = <134 nmol/g dry wt

Sample type and Volume required: 
~10 g stool specimen in a plain universal container. Specimens should be protected from light.
Turnaround time: 
2-3 weeks
Storage and transport: 
Specimens can be sent by first class post without ice packs. Specimens are stable for several weeks if frozen while awaiting despatch.
Contacts:
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Porphyrins and Gastrointestinal Laboratory at King's College Hospital
Porphyrins - 020 3299 3856, Gut Permeability - 020 3299 4133
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/02/2017