Dasatinib by LC-MS/MS
Clinical details: 
Dasatinib (Sprycel, Bristol-Myers Squibb) is a second-generation tyrosine kinase inhibitor (TKI). It is used in the treatment of chronic myeloid leukaemia (CML) in patients who have primary resistance to imatinib, which may occur in 15-20 % of cases. Treatment failure has been attributed to poor adherence or inadequate dosage. Thus, monitoring plasma dasatinib may help in assessing adherence and in optimising treatment. A target range for plasma dasatinib during effective therapy has not been established as yet. However, in patients (N = 33) prescribed (median, range) 100 (50-150) mg/d dasatinib for CML the median (range) pre-dose plasma dasatinib concentration was 13 (2-143) µg/L.
Sample type and Volume required: 
2mL EDTA whole blood or 1 mL plasma or serum (pre-dose or ‘trough’ sample).
Turnaround time: 
5 working days
Storage and transport: 
Please refrigerate (if possible) if not sending immediately. Send by first class post.
Toxicology Department at King's Hospital
020 3299 5881
King's College Hospital
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015