Metanephrines (Urine)

Urine metanephrines measured by LC-MS
Clinical details: 
Catecholamines are a group of biogenic amines derived from the amino acid tyrosine and bearing the catechol (3,4-dihydroxyphenyl)-moiety. The group comprises of adrenaline, noradrenaline and dopamine. Measurement of these catecholamines is useful in the diagnosis of neurochromaffin tumours (phaeochromocytoma, neuroblastoma and paragangliomas). Catecholamine secreting tumours account for <0.5% of all hypertensive patients and measuring these biogenic amines is useful for screening purposes.

Noradrenaline and adrenaline are catalysed by catechol-O-methyl transferase to form normetanephrine and metanephrine respectively. Many clinical studies have shown the analysis of urine metanephrines to be more sensitive in phaeochromcytoma diagnosis than urine catecholamines.
Reference range: 

Hypertension population: Urine Normetnephrine = < 4.4µmol/24hr, Urine Metanephrine = < 2.0 µmol/24hr

Healthy individuals: Urine Normetnephrine = < 1.95 µmol/24hr Urine, Urine Metanephrine = < 1.52 µmol/24hr

Sample type and Volume required: 
Sample – plain 24hr urine collection (acidified urine is also acceptable.)
Turnaround time: 
7 working days.
Storage and transport: 
Send the completed 24 hour urine collection to the Central Specimen Reception laboratory ASAP.
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Metabolic Laboratory at King's College Hospital
020 3299 4128
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 11/09/2018