TSH Receptor Antibodies (TRAb)
Description:
Measurement of TRAb is of value in outcome prediction and monitoring of treatment in Graves' disease (GD). It is also used to distinguish GD from other thyroid disease (i.e. toxic nodular goitre). TRAb measurement is indicated for pregnant patients with a history of thyroid disease in order to assess the risk of the neonate developing thyroid disease.
Clinical details:
Autoantibodies to the TSH receptor are involved in the pathology of Graves’ disease (GD) where antibodies bind to receptors and mimic the effects of TSH in an uncontrolled way. In pregnancy, trans-placental transfer of TRAb in the third trimester can give rise to neonatal thyrotoxicosis.
Reference range:
See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'
Units:
U/L
Department:
Location:
Sample type and Volume required:
Clotted (yellow SST tube). Serum.
Turnaround time:
3 days
Special sample instructions:
Take sample to specimen reception immediately after collection. Separate and freeze sample straight away. Ship frozen.
Storage and transport:
Sample stable for 3 days at 2-8C, 1 month at -20C
Contacts:
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
Last updated: 06/04/2023
