Laboratory overview

The Advanced Diagnostic Laboratory performs the assays and tests that are required for the more complex cases received in Histopathology. The range of services provided encompasses immunocytochemistry and molecular pathology.

Whilst most of this work is performed on cancers, our workload is not exclusive to that. We carry a portfolio of approximately 170 antibodies including Her2.

We also offer 8 FISH assays (inc Her2) and 8 molecular assays for solid tumours.

Key features:

Other Testing includes:

Her 2 IHC and FISH for breast and gastric samples
Interphase FISH analysis for translocations in lymphomas
KRAS, BRAF, NRAS, EGFR testing
Microsatellite instability (MSI) and mismatch repair protein analysis
IgH and TCR gene rearrangements for B and T cell clonality
Full immunohistochemistry service
Clinically Relevant Cancer Panel by Next Generation Sequencing
Immunofluorescence for skin biopsies

Referred tests:
Any immunohistochemistry tests not in our repertoire is sent to St Thomas’s Hospital (STH) or Health Service Laboratories (HSL) – AD for processing.

Molecular testing (Referral):
GIST testing is sent to Birmingham Hospital
ROS1 FISH is sent to GSTT
FISH not in our repertoire is sent to various hospitals (LMH, Leeds, GOSH, Marsden)

Renal Specimens:
All renal specimens sent to the Histopathology department, are processed at STH.