Sirolimus
Description:
Therapeutic drug monitoring for patients on immunosuppressant drugs. Analysis is by liquid chromatography - tandem mass spectrometry. Assay run every day including weekends and bank holidays. For same-day analysis, samples must be received by the laboratory by 14:00 on weekdays, and 10:30 at weekends/bank holidays. If the sample is not received before 10.30, it will be analysed and the result reported the following day. Please give the laboratory prior notice by calling on 020 3299 3147 if you are sending urgent samples at the weekend/bank holiday. Normal weekday hours are Mon-Fri 09:00 – 17:00. Weekend and bank holiday working hours are 09:30-14:00 (except bank holiday Mondays which remain 09:00-17:30). Please send a request form with adequate patient information and clear contact details to enable efficient communication of results out of hours.
This test is not currently included in the laboratory's UKAS scope of accreditation to ISO15189:2012
This test is not currently included in the laboratory's UKAS scope of accreditation to ISO15189:2012
Clinical details:
Sirolimus is an immunosuppressive agent which exerts it's effect by inhibiting the activation of T and B cells of the immue system. It is important to monitor the blood concentration of sirolimus as at toxic concentrations patients are susceptible to a number of side-effects. At sub-therapeutic dosage patients may experience transplant rejection.
Reference range:
Contact the laboratory. For clinical advice or interpretation of results please contact the laboratory in the first instance.
Synonyms or keywords:
Immunosuppressant, Sir, Sirolimus
Units:
μg/L
Department:
Location:
Sample type and Volume required:
EDTA blood
Turnaround time:
1 day
Special sample instructions:
Trough sample (taken just prior to next dose) is recommended, or at least 20 hours post dose.
Storage and transport:
Refrigerate before sending by first class post. Samples should be received in the laboratory by 14:00 on weekdays and 10:30 on weekends and bank holidays for same-day results.
Contacts:
Immunosuppressive Drug Monitoring (IDM) Service
020 3299 3147
kch-tr.KCHIDMService@nhs.net
Institute of Liver Studies
3rd Floor Cheyne Wing
King's College Hospital
Denmark Hill
London
SE5 9RS
3rd Floor Cheyne Wing
King's College Hospital
Denmark Hill
London
SE5 9RS
Laboratory:
Contact: IDM Lab, 3rd Floor Cheyne Wing, King’s College Hospital, Denmark Hill, London, SE5 9RS. Telephone: 020 3299 3147.
Last updated: 13/02/2024
