Rh/ K phenotyping

Besides the RhD (RH1) antigen, other important antigens of the Rh system (ISBT, number 004) are: C (RH2), E (RH3), c (RH4) and e (RH5). Appropriate antigen-positive red cells may stimulate antibody production in antigen C (RH2), c (RH4), E (RH3) and e (RH5) negative individuals. The determination of the Rh phenotypes can, therefore be important during pregnancy, for previously transfused patients and for patients with known irregular antibodies. Approximately 9% of the Caucasian population are K (KEL1, K, K1) positive. The K antigen is strongly immunogenic. Anti-K has been reported as the cause of hemolytic transfusion reactions, both immediate and delayed, and hemolytic disease of the newborn.
Reference range: 


Sample type and Volume required: 
6ml K2EDTA
Call in advance: 
Turnaround time: 
4 hours
Time limit for extra tests: 
1 day
Blood Transfusion Laboratory at King's
Bessemer Wing
King's College Hospital
Bessemer Wing
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 14/01/2021