Platelet Aggregation Study

Platelet function studies may be performed if a patient has a bleeding disorder with a normal or relatively normal coagulation screen and platelet count. Typically the type of bleeding will be 'mucosal' i.e. nose bleeds, bruising, menorrhagia.

Platelet clumping can be induced by the addition of various aggregation agents (agonists) to platelet rich plasma (PRP). A platelet aggregometer is used to measure the changes in light transmission through PRP upon the addition of the agonist. Light transmission will increase as the platelets aggregate. The responses of patient plasma are compared to those of a normal control. Information about percentage aggregation over time, slope analysis and slope shape with particular agonists can contribute to diagnosis of platelet function disorder.
Reference range: 

The normal control must demonstrate a normal response to the agonists used

Sample type and Volume required: 
Four x 5 ml coagulation citrated tubes. The blood must be obtained by clean venepuncture with minimal arm stasis. There must be no clots or haemolysis. The tubes must be mixed gently.
Turnaround time: 
Printed report available within 3 hours of sample reception
Storage and transport: 
An appointment must be booked with the Haemostasis laboratory in advance. The samples must be delivered to the haemostasis staff immediately to ensure specimens are not high spun in error. Keep at room temperature
Please contact Business Development for pricing enquiries
Time limit for extra tests: 
2 hours
Routine Coagulation - Blood Sciences at King's College Hospital
020 3299 2434
King's College Hospital
Bessemer Wing
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015