PAI-1 4G/5G Promoter Polymorphism

Description: 
Direct detection of a single base deletion at nucleotide -675 (4G/5G) in the promoter of the PAI-1 (SERPINE1) gene.
Clinical details: 
The presence of the single base deletion (4G/5G or 4G/4G) results in elevated levels of PAI-1 protein which can suppress fibrinolysis. Some studies have associated the 4G allele with an increased risk of thrombosis, MI, fetal loss and pre-eclampsia, although other studies dispute this. It is probable that only homozygosity (4G/4G) has any significance.
Related condition or disease: 
Possible association with thrombophilia, MI, fetal loss and pre-eclampsia.
Reference range: 

n/a

Synonyms or keywords: 
PAI-1 SERPINE1 4G/5G
Units: 
n/a
Department: 
Haemostasis and Thrombosis Department
Location: 
St Thomas' Hospital
Sample type and Volume required: 
1 x Edta
Call in advance: 
no
Turnaround time: 
14 days
Criteria for acceptance / rejections of sample
Storage and transport: 
transport at ambient temperature
Contacts:
Molecular Haemostasis Laboratory at St Thomas'
020 7188 2798
Haemostasis and Thrombosis
North Wing - 4th floor
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH

Laboratory opening times
Monday - Friday 09.00 - 17.00
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Molecular Haemostasis Laboratory at St Thomas'

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Last updated: 14/03/2017