Neuronal Antibodies

Paraneoplastic neurological syndromes can be associated with the prescence of neuronal antibodies. These are disorders of the nervous system associated with but not directly related to a primary tumour or its metastases. They can affect the nervous system causing a variety of central and peripheral nervous system syndromes that are often far more debilitating than cancer itself. The paraneoplastic symptoms can develop months or even years before the cancer can be detected, symptoms can develop rapidly over days, weeks or months rather than the expected development over years. The disability to the nervous system is often extremely severe with effects such as ataxia, dysarthria, dysphagia and nystagmus. We can detect up to six different antibodies which include anti-Hu, anti-Yo (Purkinje cell), anti-Ri, anti-Tr, anti-amphiphysin and anti-CV2/CRMP-5.
Reference range: 


Negative / Positive
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
28 days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/03/2017