Myxoid/round cell liposarcoma

Available tests Fluorescence in situ hybridisation analysis for: FUS t(16p11;); CHOP (DDIT3) t(12q13;); EWSR1 t(22q12;)
Clinical details: 
Myxoid/round cell liposarcoma is characterised by rearrangement of CHOP (DDIT3), most commonoy with FUS but also as a variant with EWSR1; detection of rearrangement of these genes, especially CHOP, can be useful in establishing the diagnosis of myxoid/round cell liposarcoma in histologically equivocal cases.
Synonyms or keywords: 
FUS t(16p11;) CHOP (DDIT3) t(12q13;), EWS
Sample type and Volume required: 
FFPE tissue sections – 3-4µm sections on unstained Apes slides with appropriate IHC/H&E slide for correlation
Turnaround time: 
Current service turnaround times: Urgent 2-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reprted within 21 days
Oncology Cytogenetics Laboratory at Guy's Hospital
Genetics Department
Tower Wing - 5th Floor
Guy's Hospital
Great Maze Pond
London SE1 9RT

T: 020 7188 1715
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015