Mitochondrial M2 antibodies

Mitochondrial antibodies are associated with primary biliary cirrhosis. They can be detected by IIF on a composite rodent block of mouse liver kidney and stomach. A number of different mitochondrial antibodies have been described in association with different hepatic and non-hepatic disorders. The antigenic specificities of some of the mitochondrial antibodies have been identified. The M2 antibody reacts with 2-oxo-acid dehydrogenase complex and is positive in up to 90% of primary biliary cirrhosis but may occur in other chronic liver diseases and systemic sclerosis. If clinically indicated a positive mitochondrial antibody is confirmed by a liver immunoblot.
Reference range: 

Negative, positives confirmed by titre and immunoblot

Titre, numerical value
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
4 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015