The Kleihauer test is performed in the following situations: Rh D negative women delivered of Rh D positive, 'weak D’, Du, D variant, D mosaic or D category infants or other known Rh D epitope variants. Rh D negative women delivered of infants of unknown Rh D type Rh D variant, mosaic or category women who deliver Rh D positive infants. Rh D negative women more than 20 weeks pregnant, having a sensitising event. Delivery of an Rh D Positive or D variant infant. Abortion after 20 weeks gestation. Invasive prenatal diagnosis- Amniocentesis, Chronic villus sampling, Fetal blood sampling, other intrauterine procedures. Insertion of shunts. Embryo reduction- Significant ante partum haemorrhage (APH), not normal 'spotting'. External version of Foetus (ECV). Closed abdominal injury. Ectopic pregnancy. Intrauterine death (IUD). Stillbirth. Miscarriage at > 20 weeks. Occasionally in cases of Intra Uterine Death of unknown cause where mother is Rh D positive. If the patient has recurrent bleeding a Kleihauer is performed at 2 weekly intervals, with anti-D being issued at 6 weekly intervals.