Free erythrocyte protoporphyrin (FEP)

Description: 
FEP is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King’s College Hospital. Quantitative measurement of FEP is reported with zinc protoporphyrin (ZPP) using fluorescence spectroscopy.
Clinical details: 
FEP is present in red blood cells and combines with iron to form haem. FEP is elevated in patients with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLPP).
Reference range: 

<200 nmol/L red cells

Synonyms or keywords: 
FEP
Sample type and Volume required: 
5 – 10 ml whole blood collected into EDTA or heparin. Separate red cells and plasma if delay in dispatch. Specimens should be protected from light.
Turnaround time: 
1-2 weeks
Storage and transport: 
Specimens can be sent by first class post without ice packs. Specimens are stable for several weeks if frozen while awaiting despatch.
Contacts:
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Porphyrins and Gastrointestinal Laboratory at King's College Hospital
Porphyrins - 020 3299 3856, Gut Permeability - 020 3299 4133
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/02/2017