Fluconazole by LC-MS/MS
Clinical details: 
Fluconazole is used for prophylaxis and treatment of invasive fungal infections (IFIs). The development of IFIs in patients being treated for haematological malignancies is associated with increased morbidity and mortality. As diagnosis of IFIs may be difficult, targeted prophylactic therapy is important in high-risk patients. Fluconazole has more predictable pharmacokinetics than other triazole antifungal drugs, but monitoring plasma concentration may be of use in assessing patient adherence to medication. A target range for plasma fluconazole during effective prophylactic therapy has not been established as yet. However, in patients prescribed fluconazole (200 mg/d) for prophylactic therapy the median (range) pre-dose plasma fluconazole concentration attained was 8.5 (1-20) mg/L.
Sample type and Volume required: 
2mL EDTA whole blood or 1 mL plasma or serum (pre-dose or ‘trough’ sample).
Turnaround time: 
5 working days
Storage and transport: 
Please refrigerate (if possible) if not sending immediately. Send by first class post.
Toxicology Department at King's Hospital
020 3299 5881
King's College Hospital
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015