Fibrinogen Beta -148 C>T Polymorphism

Description: 
Direct detection of the FGB -148C>T promoter polymorphism.
Clinical details: 
This polymorphism is associated with elevated plasma fibrinogen levels, with individuals with the TT genotype having significantly higher levels than CC individuals. There is an established association between raised fibrinogen levels and the risk for myocardial infaction (MI) and coronary artery disease (CAD). However, the association between FGB -148 and MI or CAD is less clear.
Related condition or disease: 
Possible
Increased thrombophilia risk
Increased risk of MI
Increased risk of CAD
Reference range: 

n/a

Synonyms or keywords: 
Fibrinogen promoter polymorphisms.
Units: 
n/a
Department: 
Haemostasis and Thrombosis Department
Location: 
St Thomas' Hospital
Sample type and Volume required: 
1 x Edta
Call in advance: 
no
Turnaround time: 
14 days
Criteria for acceptance / rejections of sample
Storage and transport: 
transport at ambient temperature
Contacts:
Molecular Haemostasis Laboratory at St Thomas'
020 7188 2798
Haemostasis and Thrombosis
North Wing - 4th floor
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH

Laboratory opening times
Monday - Friday 09.00 - 17.00
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Molecular Haemostasis Laboratory at St Thomas'

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Last updated: 14/03/2017