FGA + FGB+ FGG mutation screen

Quantitative Fibrinogen deficiency is the absence (afibrinogenemia) or reduction (hypofibrinogenemia) in plasma fibrinogen levels.
Qualitative fibronogenaemia (dysfibrogenemia) is the production of abnormal fibrinogen molecules.
All forms are caused by defects in one of three genes, FGA, FGB or FGG. The milder forms of the disorder (hypo- and dys-) have an autosomal dominant inheritance, while afibrinogenaemia is inherited in a recessive manner. The quantitative deficiencies are characterised by mucosal bleeding and menorrahgia, with CNS and umbilical haemorrhage, and recurrent pregnancy loss reported in patients with the more severe afibrinogenaemia. World wide incidence of afibrinogenaemia is 1 in 1,000,000
Dysfibrinogenaemia can have a more complex clinical presentation, with approximately 25% patients having a bleeding tendency, 25% reporting venous thrombosis and 50% being asymptomatic, but detected via routine laboratory screening. Dysfibrigenaemia may have an incidence of 15 /100,000