Faecal Calprotectin

GI Function Test: Faecal Calprotectin assayed using enzyme immunoassay.
Clinical details: 
Calprotectin is a stable protein that accounts for about 60% of neutrophil cytosolic protein. Calprotectin is released into the faeces when neutrophils gather at the site of any G.I tract inflammation. Calprotectin can provide a non-invasive, inexpensive and objective method for assessing patients for additional possible invasive procedures e.g.Colonscopy or imaging studies. The faecal calprotectin test has a relatively high specificity and sensitivity (approximately 90%) for distinguishing between non-inflammatory bowel disorders (e.g. irritable bowel syndrome) and inflammatory bowel disease (e.g. ulcerative colitis and Crohn's disease). Calprotectin will also be elevated in some cases of GI tract malignancy (e.g. colorectal cancer). Calprotectin is regularly raised in active IBD. Faecal calprotectin concentrations relate well to disease activity in the inflammatory bowel diseases and can therefore be used to monitor therapy. There is good correlation between faecal calprotectin concentration and the gold standard for inflammation ^111^Indium white cell labelling techniques. Calprotectin is a very stable protein and stool samples can be sent by post for analysis. The test is non-invasive and can be used on adults and children; the same reference range appears to apply to both.
Reference range: 

<50 µg/g faeces - this is not applicable to neonatal samples.

Please note: As of 22nd May 2017, calprotectin is now analysed using the Diasorin Liaison XL method. This gives lower results than the previously used method.

Sample type and Volume required: 
Random faecal sample (any time of day, no dietary restrictions required) in a plain universal container and approximately 1 gram in weight.

NOTE: Samples grossly contaminated with blood are unsuitable for FCALP analysis.
Turnaround time: 
14 working days.
Storage and transport: 
First class post within 4 days (temperature not to exceed 30°C during transport).
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Porphyrins and Gastrointestinal Laboratory at King's College Hospital
Porphyrins - 020 3299 3856, Gut Permeability - 020 3299 4133
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 17/04/2018