ENA (Extractable Nuclear Antigens)
Description:
The identification of autoantibodies to the ENA family is an integral component in the investigation of the rheumatological disorders.
Antibodies to SS-A (Ro) and SS-B (La) are mainly associated with Sjogren’s syndrome but may be found in SLE and less frequently in other autoimmune disorders. Anti-Sm and anti-RNP are associated with SLE and mixed connective tissue disease. Anti-Scl 70 is associated with scleroderma while anti-Jo-1 is seen in dermatomyositis.
Antibodies to SS-A (Ro) and SS-B (La) are mainly associated with Sjogren’s syndrome but may be found in SLE and less frequently in other autoimmune disorders. Anti-Sm and anti-RNP are associated with SLE and mixed connective tissue disease. Anti-Scl 70 is associated with scleroderma while anti-Jo-1 is seen in dermatomyositis.
Reference range:
Negative
Synonyms or keywords:
Sjogren's syndrome
Units:
Negative - Positive
Department:
Location:
Sample type and Volume required:
Clotted (Gold top vacutainer)
Turnaround time:
4 working days
Special sample instructions:
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Time limit for extra tests:
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
Laboratory:
Last updated: 03/11/2021
