ENA (Extractable Nuclear Antigens)

The identification of autoantibodies to the ENA family is an integral component in the investigation of the rheumatological disorders.

Antibodies to SS-A (Ro) and SS-B (La) are mainly associated with Sjogren’s syndrome but may be found in SLE and less frequently in other autoimmune disorders. Anti-Sm and anti-RNP are associated with SLE and mixed connective tissue disease. Anti-Scl 70 is associated with scleroderma while anti-Jo-1 is seen in dermatomyositis.
Reference range: 


Synonyms or keywords: 
Sjogren's syndrome
Negative - Positive
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
4 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/11/2021