dsDNA antibodies – RIA Immunoassay

Autoantibodies to double stranded DNA (dsDNA) are one of many autoantibodies to nuclear related antigens. They are of particular significance in the diagnosis and management of systemic lupus erythematosus (SLE) where there is evidence that the titre of the antibody is related to disease activity and useful in monitoring treatment. In drug induced lupus anti-dsDNA is usually negative. The antigen used in this assay is a human recombinant dsDNA.
Reference range: 

DB (DNA binding) 0 - 7

DP (Percentage binding) no range given

Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
5 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015