Array Comparative Genomic Hybridization (array CGH) is a technique for detecting genetic copy number changes across the entire genome. It has a much higher resolution than traditional G-banded chromosome analysis (0.12 vs 5-10 Megabases) and includes probes for all the established subtelomere and microdeletion/duplication syndrome regions, which previously would have required additional tests using FISH or MLPA. Array CGH will not detect balanced chromosome rearrangements or ploidy abnormalities such as triploidy.
This test is applied as the initial approach for any patient suspected of having an unbalanced chromosome abnormality and is therefore suitable for investigating genetic causes of learning difficulties, dysmorphism and congenital physical abnormalities.
Synonyms or keywords:
Karyotyping, G-banded chromosome analysis, Chromosomes, aCGH, array CGH, Chromosome, Duplication, Deletion, Trisomy, Monosomy, Karyotype.