D-dimers

Description: 
D-dimer levels are measured by latex immunoassay which employs latex particles coated with antibodies to D-dimers to capture D-dimers in the test plasma. The D-dimers act as a bridge between latex particles that leads to a degree of agglutination directly proportional to concentration, which is measured turbidimetrically.
Clinical details: 
Progressive degradation of cross-linked fibrin by plasmin leads to formation of small terminal derivates, one of which is D-dimer. Each D-fragment in a D-dimer molecule is derived from a different parent fibrin(ogen) molecule and remain joined due to cross-linking, so detection of D-dimers in plasma indicates the presence of a blood clot. Elevated D-dimers are a marker of reactive fibrinolysis and can be encountered in conditions such as DVT, PE & DIC. A normal D-dimer level has a high negative predictive value for DVT & PE.
Reference range: 

>0.55

Units: 
mg/L FEU
Sample type and Volume required: 
External requests: Citrated platelet poor plasma
400µL x 1 aliquot
Internal requests: please refer to EPR label

Turnaround time: 
4 hours
Special sample instructions: 

The sample should be analysed within 4 hours of venepuncture. Please ensure sample tubes are filled exactly to the fill-line as underfilling creates a dilution error and leads to inaccurate results

Contacts:
Diagnostic Haemostasis and Thrombosis Department
020 7188 2797
St Thomas' Hospital
North Wing - 4th and 5th Floors
Westminster Bridge Road
London SE1 7EH

Laboratory opening times
24/7
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 08/03/2017