Ciclosporin

Description: 
Ciclosporin measured by chemiluminescent assay on the ADVIA Centaur
Clinical details: 
Pre-dose whole blood sample taken in EDTA (0.5mL minimum; 12h post-dose for bd dosing).

Please submit with a request form showing the last dose, last dose time and sample time/date.
Reference range: 

Varies widely with indication and patient characteristics but usually within the range 20-350 µg/L. Please seek advice from the providers: 020 3299 3147.

Turnaround time: 
Same day Monday to Friday for samples received before 3 to 3.30 pm.
Special sample instructions: 

Interpretation is affected by indication for ciclosporin, time from start of therapy, immunosuppressant comedication and patient’s clinical condition. Results vary during co-medication with inducers and inhibitors of cytochrome P450 3A and P-glycoprotein and with liver function (see Purpose of the Test).

Storage and transport: 
Ciclosporin is stable in blood at normal ambient temperatures for several weeks. Ship adequately contained samples by 1st class mail or courier depending on urgency. Send directly to IDM Service, Institute of Liver Studies, King’s College Hospital, Denmark Hill, London SE5 9RS, UK to avoid delays.
Time limit for extra tests: 
Same day for other immunosuppressants e.g., tacrolimus, sirolimus or mycophenolate in the same sample.
Contacts:
Clinical Biochemistry - Blood Sciences at King's College Hospital
020 3299 4126
King's College Hospital
Bessemer Wing
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
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Last updated: 07/08/2015