Calcitonin measured by chemiluminescent immunoassay on the Liaison
Clinical details: 
"Calcitonin is most commonly used in the management of Medullary Thyroid Carcinoma (MTC), but raised concentrations may also be found in other malignancies such as breast, lung, pancreas, as well as phaeochromocytoma, renal failure, hyperparathyroidism and Paget's disease. In early MTC disease, basal concentrations of calcitonin may be normal. Increased sensitivity may be achieved by use of pentagastrin stimulation. Most patients with sporadic medullary thyroid cancer have high plasma calcitonin concentrations at the time of diagnosis, whilst 30% of patients with familial medullary thyroid cancer or MENII have normal concentrations at the time of diagnosis. These cases may require molecular genetic testing for the RET proto-oncogene.
Following successful surgical removal of medullary carcinoma, plasma calcitonin concentrations gradually decrease into the undetectable range over a period of several weeks.

Persistently elevated concentrations usually indicate incomplete cure. A rise in a previously undetectable or very low postoperative calcitonin concentration is highly suggestive of disease recurrence.
Reference range: 

Male: <11.8pg/mL Female: <4.8pg/mL

Sample type and Volume required: 
"400µL serum from gel sep or plain tube

Fasting samples are recommended, but not required.

Blood should be collected, allowed to clot, and the serum separated from the clot as soon as possible.

*Samples should be frozen immediately after centrifugation.*

No additives or preservatives are required to maintain integrity of the sample."
Turnaround time: 
Results within 7-10 working days
Storage and transport: 
"Serum can be transported on dry ice by courier. A minimum volume of 400µL required in a 2mL pot. Address specimens to: *Department of Clinical Biochemistry, Bessemer Wing, King’s College Hospital, Denmark Hill, London SE5 9RS*"
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Immunochemistry Laboratory at King's College Hospital
020 3299 4130
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015