C-Peptide

Description: 
C-peptide measurement by chemiluminescent immunoassay on the Immulite 2000
Clinical details: 
"C-peptide is produced by the pancreatic /beta-cells as a by-product of enzymatic cleavage of pro-insulin to insulin. Often measured alongside insulin, there are various clinical indications for c-peptide measurement. It is of use in the evaluation of fasting hypoglycaemia following surreptitious insulin injection, but may also be used in the identification of an insulin-pro C-peptide has an important role in monitoring pancreatic therapy. Following radical pancreatectomy C-peptide should be undetectable, whilst an increased concentration should be expected after successful pancreas/islet cell transplant. C-peptide has an important role in monitoring pancreatic therapy. Following radical pancreatectomy C-peptide should be undetectable, whilst an increased concentration should be expected after successful pancreas/islet cell transplant.

C-peptide is not affected by hepatic metabolism so may provide a better indicator of /beta-cell function than insulin. In addition, anti-insulin antibodies are often encountered in patients undergoing insulin therapy. These antibodies interfere with insulin assays and render them inappropriate for assessment of residual /beta-cell activity. C-peptide measurements may be used as an alternative to insulin in this context.ducing /beta-cell tumour. "
Reference range: 

298 – 2350 pmol/L

Units: 
pmol/L
Sample type and Volume required: 
Serum from a plain vacutainer (350 µL).
Turnaround time: 
1 month
Storage and transport: 
Send frozen on dry ice.
Contacts:
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Immunochemistry Laboratory at King's College Hospital
020 3299 4130
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 21/12/2016