C-Peptide

C-peptide is produced by the pancreatic/beta-cells as a by-product of enzymatic cleavage of pro-insulin to insulin. Often measured alongside insulin, there are various clinical indications for c-peptide measurement. It is of use in the evaluation of fasting hypoglycaemia following surreptitious insulin injection, but may also be used in the identification of an insulin-pro C-peptide has an important role in monitoring pancreatic therapy. Following radical pancreatectomy C-peptide should be undetectable, whilst an increased concentration should be expected after successful pancreas/islet cell transplant. C-peptide has an important role in monitoring pancreatic therapy. Following radical pancreatectomy C-peptide should be undetectable, whilst an increased concentration should be expected after successful pancreas/islet cell transplant.