The c-kit protein is a transmembrane tyrosine kinase receptor. Ligand binding of c-kit leads to homodimerisation and the autophosphorylation of tyrosine residues 568, 570,703, 721 and 936. Autophosphorylated tyrosine associates with proteins such as STAT leading to cell proliferation. Gain of function mutations in c-kit are found in several human tumours.
Imatinib mesylate, a selective inhibitor of tyrosine kinases (BCR-ABL, c-KIT, PDGFRA), inhibits mutant c-KIT
Synonyms or keywords:
tyrosine kinases, tyrosine kinase inhititor, c Kit , PDGFRA, gastrointestinal stromal tumours, solid cancers, imatinib, Gleevec , imatinib mesylate, melanomas.