Autoantibody panel: smooth muscle, liver/kidney microsomal, mitochondrial, gastric parietal cells

Description: 
A routine autoantibody test is performed on the traditional mouse liver, kidney, and stomach substrate by the indirect immunofluorescence method. This screening test detects anti-smooth muscle antibodies (ASM), anti-mitochondrial antibodies (AMA), anti-liver/kidney microsomal antibody (LKM), and anti-gastric parietal cell antibody (GPC). Titration is performed on the positive samples. A confirmatory Autoimmune Liver Blot (extended panel) is added to identify the antigen type for the first time positive anti-LKM or anti-mitochondrial patterns.
Clinical details: 
Autoimmune Liver Diseases, Pernicious Anaemia. See individual tests for more details regarding clinical significance
Reference range: 

Negative

Synonyms or keywords: 
ASM, LKM, MITO, GPC
Units: 
GPC - (Negative or Positive) ASM, LKM and MITO - (Negative or Positive with titre)
Department: 
Diagnostic Immunology and Allergy Department
Location: 
King's College Hospital
Sample type and Volume required: 
Clotted (Gold top vacutainer) - 1ml
Turnaround time: 
4 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Criteria for acceptance / rejections of sample
Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Contacts:
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Diagnostic Immunology Laboratory at King's

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Last updated: 09/08/2022