LKM1 blot (Part of liver immunoblot panel)

Part of Liver immunoblot panel, includes M2, LKM, LC-1 and SLA antibodies.
Antibodies to liver and kidney microsomes are characteristically associated with Type 2 autoimmune hepatitis. They may develop transiently after viral hepatitis. The antibody is tested for by IIF using a rodent composite block of liver, kidney and stomach. Sub-types of anti-LKM have been described, anti-LKM 1, 2 and 3, based on the IIF staining pattern. It can be difficult to detect in the presence of anti-gastric parietal cell antibody and requires experience to be able distinguish these patterns. The laboratory routinely reports anti-LKM 1 antibodies and this done after confirmation by autoimmune liver blot and a titre result issued.
Reference range: 

Negative / positive.

Negative - equivocal - positive
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
6 days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Storage and transport: 
Samples may be stored at 4°C prior to despatch. The use of first class letter post without the need for coolant is sufficient.
Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 01/03/2019