Centromere antibodies

Anti-centromere antibody is associated with CREST syndrome. It is not however an exclusive association as this autoantibody has been detected in other rheumatological disorders including systemic lupus erythematosus (SLE). This investigation is currently performed by indirect immunofluorescence using a HEp-2 cell line.

Reference range: 


Synonyms or keywords: 
Negative / positive
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
4 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/03/2017