Cardiolipin antibodies

Anti-phospholipid syndrome (APS), also known as Hughes syndrome presents classically with thrombosis in major arteries and veins, myocardial, pulmonary and cerebral infarction in the young and recurrent miscarriage. APS is characterized by the presence of autoantibodies to a variety of phospholipid molecules, among which is cardiolipin. The detection of anti-cardiolipin antibodies (ACA) is a major part of the laboratory investigation of APS and of systemic lupus erythematosus (SLE) where up to 50% of patients have these autoantibodies. Both IgG and IgM autoantibodies are of clinical relevance and our anti-cardiolipin assay tests for both antibodies.
Reference range: 

Anti cardiolipin IgG, <10
Anti cardiolipin IgM, <10

Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
14 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015