Alveolar rhabdomyosarcoma (ARMS)

Description: 
Available test Fluorescence in situ hybridisation analysis for FKHR (FOXO1A) t(13q14;)
Clinical details: 
Alveolar rhabdomyosarcoma (ARMS) can generally be distinguished from other round cell tumours by histology and immunohistochemistry, but approximately 80% of ARMS cases rearrangement of FKHR (FOXO1A) and the detection of such abnormalities by FISH can be important in confirming the diagnosis and distinguishing ARMS from embryonal rhabdomyosarcoma, which does not show FKHR rearrangement.
Synonyms or keywords: 
Alveolar rhabdomyosarcoma, ARMS, FKHR, FOXO1A
Department: 
Sample type and Volume required: 
FFPE tissue sections – 3-4µm sections on unstained Apes slides with appropriate IHC/H&E slide for correlation
Turnaround time: 
Current service turnaround times: Urgent 2-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reprted within 21 days
Contacts:
Oncology Cytogenetics Laboratory at Guy's Hospital
Genetics Department
Tower Wing - 5th Floor
Guy's Hospital
Great Maze Pond
London SE1 9RT

T: 020 7188 1715
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015