Renin and aldosterone assayed by chemiluminescent immunoassay using the Diasorin Liaison
Clinical details: 
The renin-angiotensin-aldosterone axis plays a vital role in sodium homeostasis and maintenance of blood volume and pressure. Disorders of the renin-angiotensin-aldosterone axis can lead to major metabolic imbalances and disease. Renin, aldosterone and their ratio are the most frequently measured parameters used to assess renin-angiotensin-aldosterone axis integrity.

Assessment of the renin-angiotensin-aldosterone axis has assumed a much greater role in clinical practice, particularly in the evaluation of patients with hypertension.

In addition, the axis is often evaluated in patients with:

- Hypo or hyperkalaemia who may have hyperaldosteronism (or other forms of genuine or apparent mineralocorticoid excess) or hypoaldosteronism respectively.

- Adrenal insufficiency - to distinguish primary from secondary cause.
Reference range: 

Renin (mU/L): Upright 5.4 - 60, Supine 5.4 - 30

Aldosterone (pmol/L): Upright 100 - 800, Supine 100 - 450

Aldo/Renin ratio: <80: Conn’s unlikely, >/=200: Conn’s likely, 80-200: Conn’s not excluded

Sample type and Volume required: 
EDTA Plasma - Process blood samples at room temperature in a non-chilled centrifuge. Plasma should be separated from cells immediately after centrifugation, aliquoted into two 2mL pots (min 500µL in each), and frozen at –20ºC.
Turnaround time: 
Results within 7-10 working days
Storage and transport: 
Plasma can be transported on dry ice by courier . A minimum volume of 500 µl required in each 2mL pot. Address specimens to: Department of Clinical Biochemistry, Bessemer Wing, King’s College Hospital, Denmark Hill, London SE5 9RS
Reference Biochemistry Department at King's College Hospital
020 3299 4107
King's College Hospital
Denmark Hill
London SE5 9RS
Immunochemistry Laboratory at King's College Hospital
020 3299 4130
King's College Hospital
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015