11 Deoxycortisol
Description:
Measurement of 11-Deoxycortisol is used in the diagnosis and management of patients with congenital adrenal hyperplasia due to 11-hydroxylase deficiency. It is also used to assess the adrenal response to metyrapone in patients with Cushing's syndrome. Please note, method of analysis is LC-MS/MS.
Clinical details:
Measurement of 11-Deoxycortisol is used in:
1) Diagnosis of and monitoring therapeutic response in, congenital adrenal hyperplasia due to 11 -hydroxylase deficiency. 11-Deoxycortisol
accumulates in the peripheral circulation when there is a deficiency of 11 -hydroxylase activity. 11-Deoxycortisol should be measured when congenital adrenal hyperplasia is suspected on clinical grounds but serum 17-hydroxyprogesterone values are equivocal.
2) Assessment of adrenal response in the metyrapone test. Metyrapone is an inhibitor of 11 -hydroxylase activity. In the differential diagnosis of Cushing’s syndrome, metyrapone is given and subsequent changes in serum concentrations of 11-deoxycortisol provide strong (but not absolute) indicators of the site of the primary lesion.
1) Diagnosis of and monitoring therapeutic response in, congenital adrenal hyperplasia due to 11 -hydroxylase deficiency. 11-Deoxycortisol
accumulates in the peripheral circulation when there is a deficiency of 11 -hydroxylase activity. 11-Deoxycortisol should be measured when congenital adrenal hyperplasia is suspected on clinical grounds but serum 17-hydroxyprogesterone values are equivocal.
2) Assessment of adrenal response in the metyrapone test. Metyrapone is an inhibitor of 11 -hydroxylase activity. In the differential diagnosis of Cushing’s syndrome, metyrapone is given and subsequent changes in serum concentrations of 11-deoxycortisol provide strong (but not absolute) indicators of the site of the primary lesion.
Reference range:
Adult reference range 0.7 – 2.7 nmol/L. No specific paediatric reference range quoted, however each result will have interpretative comments. Please contact the laboratory if you wish to discuss.
Synonyms or keywords:
11-Deoxycortisol, Deoxycortisol
Units:
nmol/L
Department:
Location:
Sample type and Volume required:
Clotted (yellow SST) preferred, but EDTA plasma also accepted. Volume required: 250uL; Absolute minimum required: 100uL.
Turnaround time:
7 working days
Special sample instructions:
In neonates the sample should be taken at least 48 hours post birth.
Storage and transport:
Store at 2-8°C and send by 1st class post. If there is a delay in postage (> 3 weeks) please store at -20°C and send frozen.
Contacts:
Steroid Laboratory at King's College Hospital
020 3299 4131
King's College Hospital
Denmark Hill
London SE5 9RS
Denmark Hill
London SE5 9RS
Laboratory:
Last updated: 06/08/2021
